Bystander effect cells

Author: zmhm

August undefined, 2024

WebJun 25, 2024 · In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded … WebActivation occurs due to a combination of an inflammatory milieu, co-signaling ligands, and interactions with neighboring cells. In this review, we will discuss the studies …

Pharmaceutics Free Full-Text Advances in Targeted Therapy of …

WebThe radiation-induced bystander effect ( bystander effect) is the phenomenon in which unirradiated cells exhibit irradiated effects as a result of signals received from nearby irradiated cells. In November 1992, Hatsumi Nagasawa and John B. Little first reported this radiobiological phenomenon. [1] WebFeb 1, 2024 · Based on the heterogeneous distribution (resulting in physical separation between ADC-targeted and ADC-untargeted cells), PHTX 11C and HEK293-GCC were selected for studying bystander effects. HEK293-GCC is a cell-based system that can be used to derive tumor spheroids for 3D tissue culture studies while the PHTX 11C … chippendale farms farmington mn

FAP-targeted CAR-T suppresses MDSCs recruitment to improve …

WebFeb 9, 2012 · Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. Cellular senescence is a state of irreversible cell cycle arrest, typically driven by a persistent DNA damage response (DDR) (Campisi & d’Adda di Fagagna, 2007). WebMar 19, 2024 · As stated before, the bystander killing effect is the property of certain ADCs to elicit antitumor activity against cancer cells located near targeted Ag + cells, regardless of target Ag expression [4, 6].This pharmacological characteristic seems to be strictly related to the ADC design, in particular to the biochemical features of the linker and the payload. WebFeb 28, 2024 · Wells and colleagues discuss emerging insights into bystander T cells, including analytical methods, the role of bystander T cell subtypes in tumor immunology and the potential ways that these ... granule bound starch synthase

Bystander Effect - an overview ScienceDirect Topics

WebJan 23, 2015 · The rescue effect describes the phenomenon where irradiated cells or organisms derive benefits from the feedback signals sent from the bystander unirradiated cells or organisms. An example of the benefit is the mitigation of radiation-induced DNA damages in the irradiated cells. The rescue effect can compromise the efficacy of … WebMar 17, 2024 · The cytotoxic payload may kill cancer cells as a result of DNA damage. Cancer cells may also be inhibited by microtubule disrupting agents. Some membrane permeable payloads (e.g., SN-38) can cross the cell membrane and exert a cytotoxic killing effect on bystander cancer cells, which may or may not express target antigens [2,6]. chippendale folding chairsWebJan 9, 2015 · We assessed the effect of apoptotic bystander cells on a T cell ELISPOT assay by selectively inducing B cell apoptosis using α-CD20 mAbs. The presence of large numbers of apoptotic B cells did not affect T cell functionality. In contrast, when PBMC were stored under unfavorable conditions, leading to damage and apoptosis in the T cells as … granule cell of the cerebellum

"WebApr 17, 2007 · The dead cells with compromised membrane integrity became permeable to PI, and their nuclei appeared either red (paclitaxel treated) or yellow (CMFDA-labeled cells, indicative of bystander effect). Cell images were captured using a Nikon fluorescent microscope (Eclipse TE300). " - Bystander effect cells

Bystander effect cells

Cellular internalization of bystander nanomaterial induced by TAT ...

WebBystander Effect: #N# What Is the Bystander Effect? #N# WebA bystander effect occurs when nontransduced or genetically unmodified cells are killed during death of transduced tumor cells [12] (Figure 6.2).This phenomenon was first suggested by Moolten and later elucidated by Culver et al [13,14].The bystander effect plays a crucial role in tumor regression because even under the best conditions, …

Did you know?

WebMeanwhile, we further analyzed the effect of suicide gene on the bystander effect of HT29-DF cells over time. The results showed that the proliferation of HT29-DF cells was inhibited as the GCV treatment time increased compared with the control (treated with PBS) group . Effects of MSCs-DF on tumor growth WebMar 22, 2024 · The bystander effect requires the payload to cross the cell membrane, hence the non-polar payloads released by cleavable linker are preferred as polar molecules are more likely to remain in cells. 263

WebOct 3, 2005 · The mechanism of the radiation-induced bystander effect, whether involving cell–cell contact or mediated by soluble factors, is not clear, is likely to be complex, and involves multiple pathways. It is, however, clear that p53 gene function is not necessary for the effect, because cells without normal p53 function (such as Chinese hamster ... WebMeanwhile, we further analyzed the effect of suicide gene on the bystander effect of HT29-DF cells over time. The results showed that the proliferation of HT29-DF cells was …

WebOct 4, 2002 · Studies in recent years have demonstrated that a radiobiologic phenomenon termed the “bystander effect” can be observed in mammalian cells grown in vitro. … WebThe bystander effect refers to the induction of biological effects in cells that are not directly traversed by a charged particle. The data available concerning the bystander effect fall into two quite separate categories, and it is not certain that the two groups of experiments are addressing the same phenomenon.

WebJul 9, 2015 · INTRODUCTION. Cells traversed by direct irradiation can be affected biologically; non-traversed adjacent cells are also affected by a biological response called the radiation-induced bystander effect (RIBE) [].This response is generated through gap junction intercellular communication (GJIC) between the target and adjacent cells by …

WebMar 16, 2024 · Radiation-induced bystander effects (RIBE) describe the biological events occurring in non-targeted cells in the vicinity of irradiated ones. Various experimental procedures have been used to investigate RIBE. Interestingly, most micro-irradiation experiments have been performed with alpha particles … chippendale folding card tableWebDec 1, 2024 · However, the effect of these therapies on bystander activation of T cells will require in-depth examination to provide insight into developing improved anticancer treatments. The contribution of bystander T cells during cancer immunotherapy or other regimens remains an open question but, nevertheless, one which will also be crucial for ... chippendale foundationWebApr 12, 2012 · ROS has been considered as one of the key mediators for bystander effects in other cell types. 35,36 It has been reported that irradiated stromal cells can induce free radicals in nonirradiated cells in a coculture system 37 as well as in directly irradiated cells. 38 A previous study demonstrated an increased level of ROS in serially ... chippendale flaxbyWebDec 11, 2024 · During viral infections, significant numbers of T cells are activated in a T cell receptor-independent and cytokine-dependent manner, a phenomenon referred to as “bystander activation.” chippendale foot stool with claw feetWebMay 9, 2024 · Treating cells and observing the behavior of adjacent cells have been the general methods used to dissect the mechanism of the bystander effect. However, researching the bystander killing effect at the single-cell level is a more recent trend that can uncover biological signals without the influence of uncertain elements associated … chippendale flower boxesWebJun 17, 2024 · The hematopoietic system is the most sensitive to irradiation, and irradiation leads to acute hematopoietic damage by inducing cell death of all the hematopoietic … granule cell level of the cerebellumWebJan 9, 2015 · We assessed the effect of apoptotic bystander cells on a T cell ELISPOT assay by selectively inducing B cell apoptosis using α-CD20 mAbs. The presence of … granule cells are usually found in cortical