Cisplatin nephropathy

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August undefined, 2024

Webwww.karger.com WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic …

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WebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin … WebOct 6, 2016 · Cisplatin [Cis-diamminedichloroplatinum (II)] is the most nephrotoxic chemotherapeutic drug, discovered over four decades ago. Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who receive cisplatin combination chemotherapy. ims cleaning solution

Acute and chronic cisplatin nephropathy in rats.

WebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... WebDiabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress, pathologic features that are shared by many other … WebDec 13, 2024 · Cisplatin and carboplatin are platinum-based antineoplastic agents. Approximately 30% of patients receiving cisplatin have acute kidney injury (AKI), and it is not unusual for subsequent treatment to be limited [].On the other hand, carboplatin, which was developed as a derivative of cisplatin in the same platinum formulation, is … lithium selenide chemical formula

Cancers Free Full-Text The Onco-Nephrology Field: The Role of ...

Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy ...

WebIn order to confirm the additional adverse effects of KU55933 on cisplatin-induced DNA damage and to elucidate the For all groups, data are means ± SEM, *p < 0.05 vs control, # p < 0.05 vs ... WebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … ims clgWebApr 12, 2024 · Cisplatin is a highly effective anti-cancer agent used in the treatment of solid organ tumors, such as head and neck, lung, breast, testis, and ovarian cancers 1, 2. Although cisplatin has... ims clinton iowa

"WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … " - Cisplatin nephropathy

Cisplatin nephropathy

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. WebOct 1, 2024 · We identified Compound-6c(Cpd-6c) as having the best activity and examined its protective effect against cisplatin nephropathy both in vivo and in vitro in cisplatin-stimulated tubular epithelial cells (TECs). Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea nitrogen and …

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WebJul 22, 2024 · Cisplatin nephropathy is a representative chemotherapeutic agent-related AKI. The molecular mechanisms underlying cisplatin-induced AKI have long been the subjects of research, and a number of studies have demonstrated the involvement of mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis in renal tubular … WebJul 7, 2007 · Despite the clinical effectiveness of cisplatin as an anti-tumour drug, its nephrotoxic side effect has significantly restricted its use. In spite of prophylactic …

WebCisplatin ATN AKI, hypomagnesemia, renal sodium Chronic interstitial ﬁbrosis and cyst formation wasting, CKD Ifosfamide ATN Fanconi syndrome (partial or complete) AKI ESRD Methotrexate Crystal nephropathy Nonoliguric AKI Pemetrexed ATN AKI AIN CKD Tubular atrophy and interstitial ﬁbrosis Nephrogenic diabetes insipidus Ipilimumab AIN AKI WebMay 1, 2008 · Cisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity leading to tubular and inflammation. Renoprotective approaches are being discovered, but the protective effects are mostly partial, suggesting the need for combinatorial strategies.

WebSep 15, 2008 · In thrombotic microangiopathy, organ damage is caused by platelet thrombi in the microcirculation, as in thrombotic thrombocytopenic purpura. 30 Mechanisms of renal injury secondary to drug-induced... Webcisplatin-induced nephrotoxicity has not been well studied. Intracellular Events that Damage Renal Cells The in vivo mechanisms of cisplatin nephrotoxic-ity are …

WebOct 22, 2024 · Cisplatin is a commonly used anticancer drug, but nephrotoxicity is a dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of...

ims climate archieveWebKidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease. ims clinic las vegasWebNational Center for Biotechnology Information imsc libraryWebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, ims cleveland ohioWebNational Center for Biotechnology Information ims clinicWebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... ims clothing companyWebNov 11, 2024 · Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors ( Dasari and Tchounwou, 2014 ). However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity ( Zhu et al., 2015 ). ims clips