Cisplatin sensitivity

Author: qrxb

August undefined, 2024

WebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to … Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need …

Cisplatin and the sensitive cell Nature Medicine

WebMay 18, 2024 · Cisplatin is the first-line platinum-based chemotherapeutic drug of OV. Most patients initially show response to chemotherapy, but more than 70% will develop recurrent disease in three years [ 2 ]. Chemoresistance limits the survival of patients with advanced cancer who receive chemotherapy [ 3 ]. WebJan 4, 2024 · Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of such resistance remain elusive. The RNA binding protein with multiple splicing (RBPMS) binds to nascent RNA transcripts and regulates splicing, transport, localization, and stability. chipotle mn locations

Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin …

WebAug 24, 2024 · Cisplatin (CDDP) remains one of the most widely used first-line drugs in the therapy of NSCLC, based on the clinical data that the poor outcomes of untreated … WebJul 26, 2024 · Background: Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its … WebSensitivity to cisplatin in the different groups was measured as the IC 50 concentration after transfection. Growth inhibition rate of the A549 cells was 52.0% under the effect of cisplatin at an IC 50 concentration of 0.8 μg/mL but decreased to 37.6% after transfection with miR-195-5p-ASO. chipotle mohegan lake

Bonn researchers elucidate a mechanism underlying …

Cisplatin and the sensitive cell Nature Medicine

WebMar 8, 2024 · XPV fibroblasts are sensitive to UV light and cisplatin but are corrected by transfection of POLHcDNA [1,13]. In this context, it is reasonable to postulate that human germline POLHvariants can alter the TLS activity and thus modify the susceptibility to toxic effects of UV and cisplatin in genetically affected individuals. WebApr 1, 2024 · Abstract. NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma … gran turismo east chambleeWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... USP14 levels were higher in DDP-resistant lung cancer compared to DDP-sensitive lung ... gran turismo download pc free

"WebJul 22, 2024 · Figure 1 Olaparib and cisplatin (CDDP) in vitro sensitivities are not influenced by the BRCA1 status of TNBC cells. (A) MTT assays of MDA-MB-468, SUM1315, MDA-MB-231 and HCC1937 cells. Data are mean ± S.D. of three independent experiments. (B) Isobologram analysis of the combination of olaparib and CDDP in constant 1:1 ratio. " - Cisplatin sensitivity

Cisplatin sensitivity

CircZNF609 promotes bladder cancer progression and inhibits cisplatin …

WebFor the first time, our study implies that d-borneol enhanced cisplatin sensitivity by inducing ferroptosis, promoting autophagy and inhibiting EMT progression, thereby … WebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the …

Did you know?

WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis may be impaired, using... WebDetermining the factors that influence cellular sensitivity to cisplatin is thus important for understanding the anticancer activity of cisplatin and for developing a more effective platinum-based chemotherapy. The cytotoxicity of cisplatin arises from its ability to react with DNA and form covalent DNA adducts ( 4 ).

WebFeb 7, 2024 · The cytotoxicity of cisplatin was evaluated in six bladder cancer cell lines to compare their responses to cisplatin. The T24 cancer cells exhibited the lowest sensitivity to cisplatin and was therefore selected to explore the mechanisms of drug resistance. WebThere are, however, contradictory reports suggesting that p53 signaling may sensitize cancer cells to cisplatin. Bunz and colleagues studied the role of p53 in cisplatin resistance in a colon cancer cell line in which both copies of p53 had been somatically disrupted (Bunz et …

WebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to low dose rate irradiation (LDRI). Methods and materials: A cisplatin resistant glioma cell line U373MGCP was developed by chronic exposure of parental U373MG cells to cisplatin. . …

WebThere is no relationship between the presence or severity of Cisplatin side effects and effectiveness of cisplatin. The following side effects are common(occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up …

WebAug 1, 2024 · Excellent sensitivity of TC tumors to cisplatin treatment has made TC a highly curable disease. Two features of TC tumors contribute to cisplatin sensitivity, … gran turismo download free pcWeb2 days ago · Blockade of neddylation increases cisplatin sensitivity of testicular germ cell tumors. In turn, inhibition of the neddylation cascade leads to an accumulation of suppressor proteins and ... gran turismo fail soundWebA recent study indicated that NKX2-1 may modulate cellular sensitivity to cisplatin by modulating the β-catenin pathway through phosphorylation of AKT . We here … gran turismo facebookWebMay 14, 2024 · Cisplatin is a highly effective chemotherapy regimen for individuals with BCa. However, cisplatin-based chemotherapy would be effective in less than 50% of BCa patients (Sagalowsky 2013 ). Cell-cycle regulation is one of the major determinants of cisplatin chemosensitivity (Yang et al. 2024; Borst et al. 2014 ). chipotle monmouth mallWebMay 17, 2012 · Cisplatin sensitivity correlated with the expression of 454 unique genes (P<0.01), corresponding to 68 pathways. Twenty-three of … chipotle monroe ohioWebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … chipotle monona wiWebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with … gran turismo east atlanta