Higuchi and connors

Author: ldyx

August undefined, 2024

WebIn vitro transdermal permeation behavior of isosorbide dinitrate in the absence and presence of 2-hydroxypropyl-β-cyclodextrin: solutions and suspensions. Interactions of a vasodilator, isosorbide dinitrate (ISDN), with the parent α-, β- and γ-cyclodextrins (α-, β- and γ-CDs) and 2-hydroxypropyl-α- and -β- and γ-CDs (HP-α- and -β ... WebT. Higuchi and K. A. Connors, “Phase-Solubility Tech-niques,” Advances in Analytical Chemistry and Instru-mentation, Vol. 53, No. 4, 1965, pp. 117-212. - References - Scientific …

Analysis of the phase solubility diagram of a …

WebJan 15, 2024 · Natural CDs and their derivatives are used as enabling pharmaceutical excipients that enhance aqueous solubility of poorly soluble drugs, increase drug permeability through biological membranes and improve drug bioavailability. WebHiguchi and Gensch, "Acylation through a Sulfonium Ion Intermediate. Coupled Conversion of a Carboxylic Acid to an Acid Anhydride during Oxidation of a Thioether to a Sulfoxide,", … rdr2 black and white

Drug/cyclodextrin: beyond inclusion complexation

WebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ( [H 4 MGF] = f ( [βCD])) of saturated solutions in mangiferin must show a linear trend and then equation ( 6) relates the slope ( α) and intercept ( G0) of the straight line with the equilibrium … WebFeb 27, 2010 · According to Higuchi and Connors there can be five types of phase-solubility relationship (Fig. 1 ): A L -type where there is a linear relationship between substrate (drug) solubility and ligand (cyclodextrin) concentration and which is interpreted as formation of a complex with m :1 stoichiometry; A P -type, which represents positive deviation … WebIt is a blood scihozonticide and active against all stages of Plasmodium falciparum. The drug is also used for the treatment of cerebral malaria as well as for the chloro- quine resistant cases [2-5]. Unfortunately, it is water- insoluble (17 µg/ml at room temperature) [6] and the formulation causes difficulties to the biopharmaceutical scientist. how to spell humiliating

Mangiferin/β-cyclodextrin complex: determination of the Inclusion ...

Investigation of Drug–Cyclodextrin Complexes by a Phase …

WebTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are … WebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = … rdr2 black screen after rockstar logoWebFeb 27, 2010 · According to Higuchi and Connors there can be five types of phase-solubility relationship (Fig. 1): A L-type where there is a linear relationship between substrate (drug) … rdr2 black loading screen pc

"WebDec 18, 2024 · Phase solubility test was performed according to the method of Higuchi and Connors [ 24 ]. An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter. " - Higuchi and connors

Higuchi and connors

WebPhase solubility diagrams and their classification according to Higuchi and Connors. S0 is the intrinsic solubility of drugs in aqueous medium. Source publication +4 Cyclodextrins in Drug... WebApr 7, 2024 · The most dramatic increase in solubility of curcumin was obtained more than 20 times higher by solidly dispersed complex of CUR with PEG 6000 (1:3) than its intrinsic solubility. Following the classification of Higuchi and Connors, CUR in different PEG 6000 solutions showed A N diagram.

Did you know?

WebMar 28, 2014 · Solubility studies were performed according to the method reported by Higuchi and Connors and the phase solubility diagrams were plotted. The repaglinide-nanosponges complexes were prepared, lyophilized and the resulted inclusion complexes were characterized by FT-IR and NMR. WebT K Higuchi, A Connors 31 Dec 1964 - Vol. 4, pp 212-217 About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The …

WebIn a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the … WebSolubility profiles by Higuchi and Connors theory. So is the drug intrinsic solubility in cyclodextrin absence 76 . Source publication Alternative Technologies to Improve …

WebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. …

WebThe shake-flask method is based on the phase solubility technique that was developed 40 years ago and is still the most reliable and widely used method for solubility measurement …

WebThe most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that … how to spell hummerWebThe present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ... rdr2 black shire horseWebJan 15, 2024 · Phase-solubility profiles and classification of drug/cyclodextrin complexes according to Higuchi and Connors (Higuchi and Connors, 1965). The phase solubility … how to spell humerus boneWebMay 9, 2007 · A phase solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of isoflavone in the complexation state and the obtained diagrams suggested that it forms complexes with a stoichiometry of 1:1. rdr2 black outfitWebPersonal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Higuchi and Connors, "Spectrophotometric Detection of the End Point in the Karl Fischer Titration of Water,", 1959, Box: 11, Folder: 110. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. rdr2 black screen flickeringWebMar 30, 2024 · The phase solubility study was carried out according to the method of Higuchi and Connors ( Higuchi, & Connors, 1965 ). Specifically, excessive APG (approximately 10 mg) was added to 5 mL of ethanol–water (30:70, v/v) solution containing different concentrations of OMT in the range of 5–300 mM. how to spell hummWebT. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: … rdr2 blackwater ferry job