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Toxin extrusion protein

Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters. See more The MATE proteins in bacteria, archaea and eukaryotes function as fundamental transporters of metabolic and xenobiotic organic cations. See more The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its … See more • Solute carrier family • Resistance-Nodulation-Cell Division Superfamily (RND) See more These proteins are predicted to have 12 alpha-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix. The X-ray structure of the NorM was determined to 3.65 Å, revealing an outward-facing conformation with … See more The following human genes encode MATE proteins: • SLC47A1 • SLC47A2 See more WebProtein extrusion has frustrated earlier predictions regarding its impact in the development of food products. The main reason for this disappointing performance has been its failure …

Tirbanibulin: Uses, Interactions, Mechanism of Action - DrugBank

WebSep 1, 2013 · Multidrug and toxin extrusion (MATE) proteins are the long anticipated transporters that are responsible for efflux of organic cations from cells. They were first described in bacteria in 1998 and named NorM and YdhE ( Morita et al., 1998 ). WebThere is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in cisplatin-induced nephrotoxicity. Its presence and role in the ear are unknown. Aims/Objectives . Evaluate the presence and localization of MATE1, and determine the localization of OCT2, in the cochlea. Evaluate cisplatin uptake with regard to MATE1 and ... massey university alumni shop https://crystlsd.com

Structure and function of multidrug and toxin extrusion

WebThe substrate specificities of human (h) multidrug and toxin extrusion (MATE) 1 and hMATE2-K were examined to find functional differences between these two transporters by the transfection of the cDNA of hMATE1 and hMATE2-K into HEK293 cells. WebMultidrug and toxin extrusion protein 1 DrugBank Online Multidrug and toxin extrusion protein 1 Details Name Multidrug and toxin extrusion protein 1 Synonyms MATE-1 MATE1 Solute carrier family 47 member 1 Gene Name SLC47A1 Organism Humans Amino … WebFeb 1, 2024 · The multidrug and toxic compound extrusion (MATE) family of transporters is ubiquitously expressed in organisms from several kingdoms of life, including archaea, bacteria, and plants, and exports cationic compounds using the H + or Na + gradient across plasma membranes. hydrology environment agency

Role of the Microbiome in Gut-Heart-Kidney Cross Talk

Category:Multidrug and toxin extrusion protein 1 (human) - PubChem

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Toxin extrusion protein

MATE1 - Transporters - Solvo Biotechnology

WebRenal effects: BIC is an inhibitor of organic cation transporter 2 and multidrug and toxin extrusion protein 1, so it decreases tubular secretion of creatinine. This increases serum … WebStructure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine 1 Dr. Margarete Fischer-Bosch …

Toxin extrusion protein

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WebMATE 1 Substrates Name MATE 1 Substrates Accession Number DBCAT003951 (DBCAT004044) Description Drugs that are eliminated by the MATE1 transporter, a multidrug and toxin extrusion transporter located in the apical membrane in the kidney and liver that is encoded by the SLC47A1 gene. Drugs Drugs & Drug Targets WebDec 5, 2005 · In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous …

WebJun 30, 2024 · Both uptake and efflux drug transporters are involved in kidney toxicity of some drugs. Source: reprinted from basit, radi, vaidya, karasu, prasad, ©2024. MATE, multidrug and toxin extrusion; MRP, multidrug resistance–associated protein; OAT, organic anion transporter; OCT, organic cation transporter; SGLT, sodium-glucose cotransporter. WebJul 11, 2024 · A transport assay of BBR using rat Madin–Darby canine kidney (MDCK)-multidrug and toxin extrusion protein 1 (rMate1) cells and a transcellular transport assay …

WebAmong the SLC47 family, multidrug and toxin extrusion protein 1, or MATE1 (SLC47A1), an organic cation/proton exchanger, mostly expressed in hepatocytes and renal tubular cells, … WebTwelve healthy subjects received a multidrug and toxin exclusion protein (MATE) inhibitor (pyrimethamine, 10, 25, and 75 mg) in a crossover fashion to identify an appropriate …

WebJun 1, 2024 · In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) by Madin-Darby canine kidney cells exogenously expressing the human organic cation transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).

WebEpsilon toxin (ETX) is produced by strains of Clostridium perfringens classified as type B or type D. ETX belongs to the heptameric β-pore-forming toxins including aerolysin and … hydrology educationWebJan 9, 2009 · H+/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play important roles in the renal tubular secretion of cationic drugs. We have recently identified a regulatory ... massey university auckland graduationWebProtein toxins produced by bacteria represent novel and potent cytotoxic agents that may be coupled to specific carrier ligands used for cellular targeting. Current targeted toxins are … massey university aviation managementWebMar 9, 2024 · This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. hydrology engineering firmsWebThe OCT proteins are usually 500–600 amino acids in length. Also, the SLC22A family contains the organic cation and carnitine transporters (OCTN1 and OCTN2). These transport proteins are predicted to contain 12 transmembrane domains with intracellular N- … massey university bachelor of accountancyWebApr 19, 2024 · The fungal toxin fusicoccin (FC) induces rapid cell elongation, proton extrusion and plasma membrane hyperpolarization in maize coleoptile cells. Here, these three parameters were simultaneously measured using non-abraded and non-peeled segments with the incubation medium having access to their lumen. The dose–response … hydrology explorerWebMar 1, 2009 · Recently, a multidrug and toxin extrusion (MATE) transporter protein family was identified, assigned as the SLC 47 family ( 12, 13 ). The SLC47A1 gene, with gene location 17p11.2, encodes the MATE1 transporter. Metformin is one of the substrates of this transporter ( 14 ). hydrology experiments