Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters. See more The MATE proteins in bacteria, archaea and eukaryotes function as fundamental transporters of metabolic and xenobiotic organic cations. See more The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its … See more • Solute carrier family • Resistance-Nodulation-Cell Division Superfamily (RND) See more These proteins are predicted to have 12 alpha-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix. The X-ray structure of the NorM was determined to 3.65 Å, revealing an outward-facing conformation with … See more The following human genes encode MATE proteins: • SLC47A1 • SLC47A2 See more WebProtein extrusion has frustrated earlier predictions regarding its impact in the development of food products. The main reason for this disappointing performance has been its failure …
Tirbanibulin: Uses, Interactions, Mechanism of Action - DrugBank
WebSep 1, 2013 · Multidrug and toxin extrusion (MATE) proteins are the long anticipated transporters that are responsible for efflux of organic cations from cells. They were first described in bacteria in 1998 and named NorM and YdhE ( Morita et al., 1998 ). WebThere is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in cisplatin-induced nephrotoxicity. Its presence and role in the ear are unknown. Aims/Objectives . Evaluate the presence and localization of MATE1, and determine the localization of OCT2, in the cochlea. Evaluate cisplatin uptake with regard to MATE1 and ... massey university alumni shop
Structure and function of multidrug and toxin extrusion
WebThe substrate specificities of human (h) multidrug and toxin extrusion (MATE) 1 and hMATE2-K were examined to find functional differences between these two transporters by the transfection of the cDNA of hMATE1 and hMATE2-K into HEK293 cells. WebMultidrug and toxin extrusion protein 1 DrugBank Online Multidrug and toxin extrusion protein 1 Details Name Multidrug and toxin extrusion protein 1 Synonyms MATE-1 MATE1 Solute carrier family 47 member 1 Gene Name SLC47A1 Organism Humans Amino … WebFeb 1, 2024 · The multidrug and toxic compound extrusion (MATE) family of transporters is ubiquitously expressed in organisms from several kingdoms of life, including archaea, bacteria, and plants, and exports cationic compounds using the H + or Na + gradient across plasma membranes. hydrology environment agency